Biyernes, Pebrero 24, 2012

Chapter 8 - Histology and Physiology of Muscles

Functions of the Muscular System
> body movement
> maintenance of body posture
> respiration
> production of body heat
> communication
> constriction of organs and vessels
> heart beat








Table. Comparison of Muscle Types                                                                                                        
                                                                          Muscle Type                                                                  
Characteristic            Skeletal                            Cardiac                              Smooth                                
 
 Nuclei                      Multinucleated;               Single nucleus; centrally    Single nucleus; centrally
                                 peripherally located         located                               located
Banding                    Actin and myosin form     Actin and myosin form        Actin and myosin; no
                                 distinctive bands              distinctive bands                 distinctive bands
Z disks                       Present                             Present                               Z disks not present; 
                                                                                                                    cytoplasmic dense bodies
                                                                                                                    are present
T tubules                  T tubules at A-I                 T tubules at Z disk;             No T tubules; no triads
                                 junction; triads                  diads present                     or diads; caveolae are
                                 present                                                                        present
Cellular                     No junctional                    Intercalated disks               Gap junctions
     junctions                        complexes   
Neuromuscular          Present                             Not present; contraction     Not present; contraction
     junctions                                                                          is intrinsic            is intrinsic, neural, or 
                                                                                                                        hormonal
Ca 2+-binding           Troponin                          Troponin                            Calmodulin
Regeneration            Limited; satellite cells       None                                 High                                      



Characteristics of Muscle
> contractility
> excitability
> extensibility
> elasticity

Muscle fibers











Sliding Filament model

Ion channels
> ligand gates
> voltage-gated ion channels



Action potentials


Neuromuscular junction





Muscle relaxation
> excitation-contraction coupling results in the release of Calcium from the sarcoplasmic reticulum and the binding  of Calcium to troponin.



Characteristics of Muscle Types

Fibre TypeType I fibresType II A fibresType II B fibres
Contraction timeSlowFastVery Fast
Size of motor neuronSmallLargeVery Large
Resistance to fatigueHighIntermediateLow
Activity Used forAerobicLong term anaerobicShort term anaerobic
Force productionLowHighVery High
Mitochondrial densityHighHighLow
Capillary densityHighIntermediateLow
Oxidative capacityHighHighLow
Glycolytic capacityLowHighHigh
Major storage fuelTriglyceridesCP, GlycogenCP, Glycogen



Types of smooth muscle


> involuntary muscle
> muscle of the viscera (e.g., in walls of blood vessels, intestine, & other 'hollow' structures and organs in the body)


Functional properties of smooth muscles


> smooth muscle is capable of authorhytmic contraction.
> a typical smooth muscles contracts and relaxes.
> smooth muscle tone.






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